Table 5.

Practical indications, listed in order of importance, when therapeutic drug monitoring of voriconazole might be useful

Clinical situation
●	Suspected treatment failure
●	Suspected suboptimal dosing - for example, due to interaction with other drugs such as phenytoin, in children or in cerebral infections Change in the administration of the drug from intravenous to oral routea
●	Suspected suboptimal absorption
●	Suspected non-compliance
●	Suspected neurologic toxicity possibly related to overdosing
●	Suspected other toxicity possibly related to overdosing

^aAs long as the patient is critical, intravenous therapy is preferred in order to avoid problems with absorption.