Table 3.
Geometric means (95% CI) of BD metabolites stratified by GSTT1 CNV and race/ethnicity (adjusted for age and sex)
|
GSTT1 copy number genotype |
All | Whites | Native Hawaiians | Japanese Americans | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| N | Geometric means (95% CL)a |
N | Geometric means (95% CL)a |
N | Geometric means (95% CL)a |
N | Geometric means (95% CL)a |
p-value | |||||
| MHBMA | |||||||||||||
| 1/1 | 128 | 11.1 | (9.5–13.0) | 59 | 11.8 | (9.5–14.5) | 49 | 10.5 | (8.3–13.3) | 20 | 11.1 | (7.7–15.9) | 0.79 |
| 1/0 | 271 | 6.7 | (6.1– 7.4) | 86 | 6.6 | (5.6– 7.9) | 97 | 6.6 | (5.6– 7.8) | 88 | 6.9 | (5.8– 8.3) | 0.92 |
| 0/0 | 184 | 2.3 | (2.1– 2.6) | 49 | 3.4 | (2.7– 4.3) | 47 | 1.7 | (1.3– 2.1)b | 88 | 2.2 | (1.9– 2.7)b | 0.0001 |
| p-value | <.0001 | <.0001 | <.0001 | <.0001 | |||||||||
| DHBMA | |||||||||||||
| 1/1 | 128 | 529.5 | (467.2–600.1) | 59 | 564.5 | (478.5–665.9) | 49 | 522.1 | (434.7–627.0) | 20 | 503.7 | (379.3–668.9) | 0.73 |
| 1/0 | 271 | 535.8 | (496.1–578.7) | 86 | 536.3 | (467.8–614.9) | 97 | 509.4 | (447.0–580.5) | 88 | 563.1 | (491.1–645.5) | 0.59 |
| 0/0 | 184 | 478.2 | (433.8–527.2) | 49 | 573.0 | (477.5–687.7) | 47 | 417.9 | (346.8–503.6)b | 88 | 456.6 | (398.6–523.1) | 0.05 |
| p-value | 0.181 | 0.818 | 0.163 | 0.099 | |||||||||
| MHBMA/(MHBMA + DHBMA) ratio | |||||||||||||
| 1/1 | 128 | 0.020 | (0.017–0.024) | 59 | 0.020 | (0.016–0.025) | 49 | 0.019 | (0.015–0.025) | 20 | 0.021 | (0.015–0.032) | 0.91 |
| 1/0 | 271 | 0.012 | (0.011–0.014) | 86 | 0.012 | (0.010–0.015) | 97 | 0.013 | (0.011–0.015) | 88 | 0.012 | (0.010–0.015) | 0.90 |
| 0/0 | 184 | 0.005 | (0.004–0.006) | 49 | 0.006 | (0.005–0.008) | 47 | 0.004 | (0.003–0.005)b | 88 | 0.005 | (0.004–0.006) | 0.08 |
| p-value | <.0001 | <.0001 | <.0001 | <.0001 | |||||||||
a
Adjusted for age, sex, BMI (natural log) and log-nicotine equivalents (natural log)
b
P-value <0.05 when compared to whites