Skip to main content
. Author manuscript; available in PMC: 2015 Sep 1.
Published in final edited form as: Epidemiology. 2014 Sep;25(5):749–761. doi: 10.1097/EDE.0000000000000121

Figure 3.

Figure 3

The four-fold decomposition encompasses both decompositions for mediation and interaction. For interaction, the reference interaction (INTref) and the mediated interaction (INTmed) combine to the portion attributable to interaction (PAI). The portion attributable to interaction (PAI) combine with the controlled direct effect (CDE) and the pure indirect effect (PIE) to give the total effect (TE). For mediation, the controlled direct effect and the reference interaction (INTref) combine to give the pure direct effect (PDE); the pure indirect effect (PIE) combines with the mediated interaction (INTmed) to give the total indirect effect (TIE); and the pure direct effect (PDE) combines with total indirect effect (TIE) to give the total effect (TE).