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Schematic models of the three alternative modes of HH processing, secretion and presentation. Paracrine signaling by processed HH is representative of what is known for mammalian SHH. Full length HH secretion has been observed for both IHH (also in association with vLDL) and here for SHH. Juxtacrine full length HH signaling has been observed here for DHH but may also be utilised by SHH and IHH.
