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Interaction between endothelial cells and vascualar smooth mucle cells mediated by endothein-1. (NO, nitric oxide; ET-1, endothelin-1; cGMP, cyclic guanosine monophosphate; CA2+, calcium ions; PKC, protein kinase C; PI3-K, phosphatidylinositol 3-kinase; AKt – Protein Kinase B; MAPK, mitogen activated protein kinase). Modified from Kohan et al. 104
