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. 2014 Oct 28;5:5339. doi: 10.1038/ncomms6339

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(a) Three live cell timelapse series showing chromosome missegregation in pkl1Δ cut7Δ double mutant cells. (b) Frequency of missegregation phenotypes across strains (n=500 cells/strain). (c) Mini chromosome loss frequency in wild type (n=0/1,011, 0%), pkl1Δ single mutant (n=316/986, 32%) and pkl1Δ cut7Δ double mutant cells (n=549/2,035, 27%). (d) pkl1Δ cut7Δ cells expressing Mad2-GFP (green) and mCherry-Atb2 (red). (e) Increased spindle microtubule density at one pole (yellow arrow) in pkl1Δ cut7Δ double mutant cells is associated with little to no Mad2-GFP polar signal in anaphase B (top images). The white arrow indicates the mother pole. Mad2-GFP is stably expressed in pkl1Δ cut7Δ cells (bottom image). In this bottom image, scale bar, 10 μm. Scale bar, 5 μm.