Figure 1.

Effects of single administration of goshajinkigan (GJG), hachimijiogan (HJG), and rokumigan (RMG) on the established mechanical allodynia after paclitaxel injection. (a) Development of mechanical allodynia after a single injection of paclitaxel. Mice were injected intraperitoneally with paclitaxel (5 mg/kg) or vehicle on day 0. GJG (b), HJG (c), RMG (d), or vehicle (5% gum arabic) was orally administered on day 14 after paclitaxel injection. Data are presented as mean and standard error of the mean (n = 5-6). *P < 0.05 compared to vehicle (Holm-Sidak multiple comparisons)