Table 2. Association of BRAFV600E and NRASQ61R mutations with melanoma risk factors.
| BRAFV600E (N=24) | NRASQ61R (N=24) | Wild-type (N=72) | BRAFV600E vs wild-type ORa (95% CI) | NRASQ61R vs wild-type ORa (95% CI) | |
|---|---|---|---|---|---|
|
| |||||
| n | |||||
| Family history of melanoma | |||||
| No | 22 | 21 | 63 | 1.00 | 1.00 |
| Yes | 2 | 3 | 9 | 0.65 (0.13, 3.23) | 0.98 (0.24, 3.99) |
| Natural hair color | |||||
| Dark brown/black | 9 | 8 | 23 | 1.00 | 1.00 |
| Light brown | 8 | 4 | 21 | 1.01 (0.33, 3.12) | 0.55 (0.14, 2.10) |
| Blonde/red | 3 | 9 | 18 | 0.43 (0.10, 1.84) | 1.50 (0.48, 4.72) |
| Ptrend | 0.30 | 0.51 | |||
| Number of moles with a diameter ≥3mm on left arm | |||||
| None | 6 | 14 | 32 | 1.00 | 1.00 |
| 1-2 | 3 | 3 | 11 | 1.45 (0.31, 6.81) | 0.60 (0.14, 2.53) |
| ≥3 | 5 | 2 | 12 | 2.26 (0.56, 9.17) | 0.40 (0.08, 2.07) |
| Ptrend | 0.25 | 0.22 | |||
| Propensity to tan as a child/adolescent | |||||
| No tan or light tan | 7 | 10 | 33 | 1.00 | 1.00 |
| Average tan | 8 | 9 | 21 | 1.86 (0.58, 5.92) | 1.44 (0.50, 4.13) |
| Deep tan | 5 | 2 | 8 | 3.08 (0.76, 12.4) | 0.84 (0.15, 4.64) |
| Ptrend | 0.10 | 0.88 | |||
| Skin reaction to sun exposure as a child/adolescent | |||||
| None or some redness | 10 | 10 | 35 | 1.00 | 1.00 |
| Burn | 6 | 6 | 12 | 1.65 (0.48, 5.68) | 1.72 (0.51, 5.78) |
| Painful burn or blisters | 4 | 5 | 15 | 0.93 (0.25, 3.43) | 1.17 (0.34, 4.02) |
| Ptrend | 0.95 | ||||
| Number of severe/blistering sunburns | |||||
| None | 7 | 9 | 29 | 1.00 | 1.00 |
| 1-2 times | 7 | 5 | 14 | 2.37 (0.67, 8.38) | 1.29 (0.33, 5.00) |
| ≥3 times | 4 | 4 | 13 | 1.38 (0.34, 5.63) | 1.09 (0.27, 4.44) |
| Ptrend | 0.51 | 0.87 | |||
| UV index at birth | |||||
| ≤5 | 5 | 4 | 17 | 1.00 | 1.00 |
| 6 | 14 | 11 | 27 | 1.72 (0.52, 5.67) | 1.62 (0.43, 6.05) |
| ≥7 | 3 | 2 | 12 | 0.86 (0.17, 4.29) | 0.70 (0.11, 4.47) |
| Ptrend | 0.99 | 0.85 | |||
| UV index at age 15 | |||||
| ≤5 | 3 | 4 | 19 | 1.00 | 1.00 |
| 6 | 15 | 11 | 27 | 3.43 (0.86, 13.6) | 1.84 (0.50, 6.72) |
| ≥7 | 4 | 2 | 10 | 2.45 (0.45, 13.3) | 0.88 (0.14, 5.75) |
| Ptrend | 0.25 | 0.90 | |||
| UV index at age 30 | |||||
| ≤5 | 3 | 5 | 17 | 1.00 | 1.00 |
| 6 | 10 | 10 | 30 | 1.82 (0.43, 7.59) | 1.04 (0.30, 3.64) |
| ≥7 | 9 | 2 | 9 | 5.54 (1.19, 25.8) | 0.69 (0.11, 4.37) |
| Ptrend | 0.02 | 0.76 | |||
a
OR values are adjusted for age at diagnosis as a continuous variable.