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. 2014 Jul 25;16(4):R158. doi: 10.1186/ar4673

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© Isaacs et al.; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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SCr changes in Phase 3 studies. (A) Mean (±SE) change from baseline in SCr (mg/dl) across the Phase 3 program (0 to 12 months). (B) SCr outliers during tofacitinib 5 mg BID treatment. (C) SCr outliers during tofacitinib 10 mg BID treatment.