Comparison of genotype frequencies (%) of C10X polymorphism (CARD8 gene) in bacteraemic patients infected with Gram-positive G+; n = 35) and Gram-negative (G−; n = 25) bacteria to healthy controls (n = 1003)
| G+ samples (%), n = 35 | Healthy controls (%), n = 1003 | OR (95% CI)a | P-valuea | G− samples (%), n = 25 | OR (95% CI)b | P-valueb | |
|---|---|---|---|---|---|---|---|
| Genotype frequencies – CARD8 | |||||||
| CC | 7 (20) | 442 (44.1) | 1 | 3 (12) | 1 | ||
| CX | 23 (65.7) | 462 (46.1) | 3.1 (1.3–7.4) | 0.009 | 17 (68) | 5.4 (1.6–18.6) | 0.007 |
| XX | 5 (14.3) | 99 (9.9) | 3.2 (1.0–10.3) | 0.052 | 5 (20) | 7.4 (1.7–31.7) | 0.007 |
| G+ samples (%), n = 70 | Healthy controls (%), n = 2006 | OR (95% CI)a | P-valuea | G− samples (%), n = 50 | OR (95% CI)b | P-valueb | |
|---|---|---|---|---|---|---|---|
| Allele frequencies – CARD8 | |||||||
| C | 37 (52.9) | 1346 (67.1) | 1 | 23 (46) | 1 | ||
| X | 33 (47.1) | 660 (32.9) | 1.8 (1.1–2.9) | 0.013 | 27 (54) | 2.4 (1.4–4.2) | 0.002 |
OR, odds ratio; CI, confidence interval.
a
Association between G+ samples (patients with Gram-positive bacteria infection) and Healthy controls.
b
Association between G− samples (patients with Gram-negative bacteria infection) and Healthy controls.