Comparison of genotype frequencies (%) of C10X polymorphism (CARD8 gene) in bacteraemic patients infected with Gram-positive (G+; n = 35) and Gram-negative (G−; n = 25) bacteria to patients with negative blood culture bottles (non-bacteraemic patients; n = 76)
| G+ samples (%), n = 35 | Non-bacteraemic samples (%), n = 76 | OR (95% CI)a | P-valuea | G− samples (%), n = 25 | OR (95% CI)b | P-valueb | |
|---|---|---|---|---|---|---|---|
| Genotype frequencies – CARD8 | |||||||
| CC | 7 (20) | 30 (39.5) | 1 | 3 (12) | 1 | ||
| CX | 23(65.7) | 42 (55.3) | 2.3 (0.9–6.2) | 0.084 | 17 (68) | 4.0(1.1–15.1) | 0.037 |
| XX | 5(14.3) | 4 (5.3) | 5.4 (1.1–25.3) | 0.034 | 5 (20) | 12.5(2.1–73.5) | 0.005 |
| G+ samples (%), n = 70 | Non-bacteraemic samples (%), n = 152 | OR (95% CI)a | P-valuea | G− samples (%), n = 50 | OR (95% CI)b | P-valueb | |
|---|---|---|---|---|---|---|---|
| Allele frequencies – CARD8 | |||||||
| C | 37 (52.9) | 102 (67.1) | 1 | 23 (46) | 1 | ||
| X | 33 (47.1) | 50 (32.9) | 1.8 (1.02–3.2) | 0.041 | 27 (54) | 2.4 (1.2–4.6) | 0.008 |
OR, odds ratio; CI, confidence interval.
a
Association between G+ samples (patients with Gram-positive bacteria infection) and non-bacteremic patients.
b
Association between G− samples (patients with Gram-negative bacteria infection) and non-bacteremic patients.