Table 2.

Peptides Tested In Vivo for Efficacy Against Ocular Pathogens

Test article	Chemical nature	Tested in	Source	Target microbe	Concentration tested	Vehicle	Model used	Effect	References
OH-CATH30	Peptide	Rabbits	King Cobra	P. aeruginosa	1 mg/mL	PBS	Abrasion	Reduced colony counts	22
RC-2	Theta defensin	Mouse	Nonhuman primate/synthetic	HSV-1	0.1% (wt/vol)	DMEM	Scarification	Reduced disease severity when used prophylactically	27
Cecropin/Melitin	Hybrid peptide	Rabbit	Cecropia moth/bee	P. aeruginosa	0.1%	PBS	Intrastromal injection	Modest reduction in disease severity	30
Nona-d-arginine	Peptide	Mouse	Synthetic	P. aeruginosa	10 and 100 μM	PBS	Scarification	Reduced colony counts	38,39
CC1A, B, C, and Col-1	Peptides	Rabbit	In silico designed synthetics	P. aeruginosa	10 and 50 μg/mL	0.5 methylcellulose±0.05% EDTA	Abrasion	Not effective	20
G1 and G2	Peptides	Mouse	Phage display synthetics	HSV-1	0.5 mM	PBS	Scarification	Reduced viral replication and less-severe disease	32
Pc-C and Pc-E	Peptides	Mouse	Synthetic	A. fumigatis	1 mg/mL	PBS	Scarification	Reduced growth, less-severe disease	40
TAT-Cdo	Peptide	Mouse	HIV tat protein/synthetic	HSV-1	1%	PBS; tears naturale; 2% methylcellulose in PBS; Aquaphor based cream	Scarification	Reduced angiogenesis and stromal disease	46
apoEdp	Peptide	Mouse/rabbit	Apolipoprotein E/synthetic	HSV-1	0.5 mM	PBS	Scarification	Very effective in reducing shedding and disease	54–55
G2-ACV	Peptide-nucleoside analog conjugate	Ex vivo porcine cornea	Synthetic	HSV-1	10 μM	Normal saline	Scarification	Reduced viral antigen in tissue—not better than ACV alone	68

ACV, Acyclovir; DMEM, Dulbecco's modified Eagle's medium; PBS, phosphate-buffered saline.