Figure 4.

Modular Single-set Enrichment Test evaluation of enrichment for mental health related gene sets within significantly altered genes in maternal NAC. (A) Y-axis represents the probability of X matches to depression and BPD databases appearing in a randomly generated set of simulated results from the microarray background. The red arrow shows how many matches were found in the actual significant postpartum NAC expression changes and where that number falls on the probability density distribution. The enrichment p-value is derived from the number of simulated results that contained at least as many matches to database as the actual results. (B) Modular Single-set Enrichment Test p-values for significant postpartum NAC genes against databases for autism, schizophrenia, arthritis, Alzheimer’s disease, and multiple sclerosis.