FIG. 6.
Antiapoptotic effects of SDF-1α on SH-SY5Y cells in vitro. (A) SH-SY5Y cells were pretreated with 1, 10, or 50 ng/mL SDF-1α for 30 min and then exposed to 1,000 μM PQ for 24 h. Treatment with 1, 10, and 50 ng/mL of SDF-1α significantly reduced apoptotic cell death compared with treatment with PBS (N=3 in each group). *P<0.05 compared with treatment with 0 ng/mL; by 2-way ANOVA. (B) Expression of the antiapoptotic protein Bcl-2 was significantly upregulated when cells were exposed to PQ and SDF-1α pretreatment. Bars show the mean±SEM. The scale bar represents 50 μm. #P<0.05 compared with normal control; by 1-way ANOVA. PBS, phosphate-buffered saline.