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. 2014 Nov 5;5:561. doi: 10.3389/fimmu.2014.00561

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Copyright © 2014 Tanaka, Ishima, Enoki, Kimachi, Shirai, Watanabe, Chuang, Maruyama and Otagiri.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of HSA–Trx on pulmonary and plasma oxidative stress in influenza-infected mice. Immunostaining of lung slice for (A) 8-OHdG/DAPI and (B) NO₂-Tyr/DAPI was performed at 8 days after the influenza infection. Image analysis of the extent and intensity of (C) 8-OHdG/DAPI and (D) NO₂-Tyr/DAPI staining was performed. (E) Plasma hydroperoxide level was determined at 8 days after influenza infection. Each bar represents the mean ± SE (n = 4).