Table 3.
Association between MeDi score and upper quartile of eGFR decline
| MeDi Score | OR (95% CI) | P Value |
|---|---|---|
| Continuous (per 1-point increase in MeDi score) | ||
| Unadjusted | 0.88 (0.80 to 0.96) | 0.01 |
| Demographic adjusteda | 0.89 (0.80 to 0.98) | 0.02 |
| Fully adjustedb | 0.88 (0.79 to 0.98) | 0.02 |
| MeDi score ≥5 (versus <5) | ||
| Unadjusted | 0.65 (0.48 to 0.88) | 0.01 |
| Demographic adjusteda | 0.65 (0.47 to 0.88) | 0.01 |
| Fully adjustedb | 0.58 (0.41 to 0.83) | 0.003 |
| MeDi quartiles (unadjusted) | ||
| 0–3 | Ref | |
| 4 | 0.81 (0.53 to 1.23) | 0.32 |
| 5 | 0.52 (0.33 to 0.82) | 0.004 |
| 6–9 | 0.63 (0.41 to 0.95) | 0.03 |
| MeDi quartiles (demographic adjusted) | ||
| 0–3 | Ref | |
| 4 | 0.86 (0.55 to 1.33) | 0.49 |
| 5 | 0.51 (0.32 to 0.81) | 0.004 |
| 6–9 | 0.66 (0.43 to 1.02) | 0.06 |
| MeDi quartiles (fully adjusted) | ||
| 0–3 | Ref | |
| 4 | 1.01 (0.62 to 1.66) | 0.96 |
| 5 | 0.49 (0.29 to 0.82) | 0.01 |
| 6–9 | 0.67 (0.41 to 1.10) | 0.11 |
a
Adjusted for age (years), sex, race/ethnicity (black, white, Hispanic, or other), education (high school completion versus not), and insurance status (Medicare/private insurance versus Medicaid/no insurance).
b
Adjusted for age (years), sex, race/ethnicity (black, white, Hispanic, other), education (high school completion versus not), insurance status (Medicare/private insurance versus Medicaid/no insurance), physical activity (any exercise versus not), BMI (kg/m2), diabetes (yes or no), smoking status (never, past, or current), hypertension (yes or no), LDL (mg/dl), HDL (mg/dl), baseline eGFR (ml/min per 1.73 m2), and ACE inhibitor/ARB usage (yes or no).