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. Author manuscript; available in PMC: 2014 Nov 5.
Published in final edited form as: Sci Signal. 2014 Feb 4;7(311):ra12. doi: 10.1126/scisignal.2004621

Fig. 7. Overall network response to motif modulation predicted by the computational model can be experimentally validated in vitro using pharmacologic agents.

Fig. 7

(A) Schematic diagram of FFM2, FBL1, and loci of pharmacological inhibition. (B) Effect of disruption of FBL1 with PDE-4 inhibitor rolipram (ISO + Roli) or disruption of FFM2 with the MEK inhibitor U0126 (ISO + Roli + U0126) during β-adrenergic stimulation with low-dose isoproterenol (0.1 μM; ISO Only) on CREB activity. Upper panel: Model predictions. Lower panel: Experimental observations.