Table 4.
Impact of co-trimoxazole prophylaxis on mortality among predominately adult patients with HIV-associated tuberculosis (TB)
| Study | Year of publication | Study design | Country | Level of bacterial resistance to co-trimoxazole | No. of study participants | Mortality reduction |
|---|---|---|---|---|---|---|
| Wiktor et al. [40] |
1999 |
Randomized controlled trial |
Cote D’Ivoire |
Low |
771 |
46% |
| Zachariah et al. [41] |
2003 |
Cohort study (‘before’ and ‘after’ study with historical controls) |
Malawi (north) |
High |
1,986 |
19% |
| Mwaungulu et al. [42] |
2004 |
Cohort study (‘before’ and ‘after’ study with historical controls) |
Malawi (south) |
High |
717 |
22% |
| Grimwade et al. [43] |
2005 |
Cohort study (‘before’ and ‘after’ study with historical controls) |
South Africa |
High |
3,325 |
29% |
| Nunn et al. [44] | 2008 | Randomized controlled trial | Zambia | High | 1,003 | 21% |