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. 2013 Nov 28;9:60. doi: 10.1186/1744-8069-9-60

Figure 6.

Figure 6

Effect of SKF 81297 on the firing properties of small DRG neurons. A) Top: current clamp protocol: 0.8 sec ramp of current to 1 nA was injected to elicit action potentials. Bottom: action potentials elicited in a small DRG neuron (diameter ≤ 25 μm) in control. B) Action potentials elicited in a different small DRG neuron (diameter ≤ 25 μm) incubated for 15 min in 10 μM SKF 81297. C) In collected results, the total number of action potentials during the first current injection decreased from 14.9 ± 3.4 (n = 15) in control to 10.0 ± 3.6 (n = 12) in 10 μM SKF 81297 (t-test, two populations **p < 0.01); the peak of the first action potential decreased from 38.4 ± 10.4 mV (n = 15) in control to 33.2 ± 7.3 mV (n = 12) in 10 μM SKF 81297 (t-test, two populations, p = 0.137); the maximum upstroke velocity of the first action potential decreased from 87.0 ± 31.9 V/sec (n = 15) in control to 77.8 ± 35.2 V/sec (n = 12) in 10 μM SKF 81297 (t-test, two populations, p = 0.484); the firing frequency decreased from 33.1 ± 7.5 Hz (n = 15) in control to 29.9 ± 13.8 Hz (n = 12) in 10 μM SKF 81297 (t-test, two populations, p = 0.459).

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