Table 1. Reproductive tissue-restricted antigens highly expressed in human mTECa.
| Placenta | Ovary | Uterus | Testis | Prostate | Pituitary | Hypothalamus | |||
|---|---|---|---|---|---|---|---|---|---|
| 3–10×Meanb | ARHGAP8 | LAMB2 | HF1 | LAMB2 | RNASE1 | ACPP | KRT19 | INSM1 | |
| CEBPB | NID1 | RBP1 | FXYD3 | CRABP1 | ARHGAP8 | NEFH | LOH11CR2A | ||
| CRIP2 | NPC1 | DLK1 | GSN | CTSF | BZRP | P24B | NTS | ||
| DAF | PRSS11 | HXB | PPFIBP2 | CCND1 | SCNN1A | GCGA | |||
| DLX5 | RDC1 | IGFBP7 | HSPA2 | CKMT1 | TPM2 | CSH2 | |||
| DUSP5 | RNASE1 | MYH11 | PRAME | CLDN4 | TSPAN-1 | ||||
| ERBB3 | S100A11 | APM2 | SERPINA5 | CLDN7 | VRP | ||||
| FSTL3 | SLC9A3R1 | VRP | STHM | DBI | |||||
| HDAC5 | SPP1 | SCGB2A1 | |||||||
| INDO | TM4SF1 | VRP | |||||||
| KRT19 | TRIM29 | ||||||||
| KRT7 | |||||||||
| 10–30×Mean | DLK1 | CHI3L1 | CCNA1 | CLDN3 | CHGB | HDC | |||
| GH1 | CYR61 | GSTM3 | ID1 | DLK1 | |||||
| CSF2RB | RAMP1 | ZNF165 | KLK11 | ||||||
| FN1 | TPM2 | SPAG6 | KRT15 | ||||||
| KRT18 | SCGB2A1 | SORD | |||||||
| PLAU | APM2 | ||||||||
| EFS2 | EFS2 | ||||||||
| SPINT1 | |||||||||
| >30×Mean | CGA | HSD17B2 | IGSF1 | ||||||
| CSH2 | PRG2 | GH1 | |||||||
| AOC1 | SDC1 | ||||||||
| CDKN2A | SERPINB2 | ||||||||
| GABRE | TFAP2A |
Abbreviation: mTEC, medulary thymic epithelial cell.
a
Data represent genes that are restricted in expression to five or fewer tissues among more than 70 tissues and cells, as determined by microarray analysis. Data from Ref. 68 were compared to the gene expression database BioGPS (http://www.BioGPS.org).
b
Genes included were separated into categories of 3- to 10-fold, 10- to 30-fold and greater than 30-fold above the mean expression across all tissues and cell lines examined.