Table 2. Reproductive tissue-restricted antigens highly expressed in mature mTEC in the mousea.
| UC | Placenta | Ovary | Uterus | MG-NL | MG-L | Testis | Prostate | Pituitary | ||
|---|---|---|---|---|---|---|---|---|---|---|
| 3–10×Meanb | Edn1 | Alb | F2c | Bhmt | Krt13 | Psp | Mup3 | Bhmt | ||
| Klk11 | Csn1s1 | Fgg | Sprr1b | |||||||
| Krt16 | Csn2 | Igf2 | ||||||||
| Tmem45a | Csn1s2a | Kng1 | ||||||||
| Ear1 | Krt13 | |||||||||
| Ear2 | Plagl1 | |||||||||
| 10–30×Mean | Asprv1 | Apoc2 | Zp2 | Mmp7 | Tnnc1 | Fbp11 | Mmp7 | Plagl1 | ||
| Cdkn1c | Cdkn1c | Zp3 | Ldh3 | Presp18 | ||||||
| Crct1 | Hbb-y | |||||||||
| Lgals7 | Krt25 | |||||||||
| Plagl1 | Procr | |||||||||
| Tac2 | Tnfrsf11b | |||||||||
| >30×Mean | Alox12b | Apoa4 | Krt16 | Areg | Csn1s1 | Ubxn11 | Pbp | Pomc1 | ||
| Calm4 | Apob | Csn2 | ||||||||
| Hbb-y | Csn1s2a | |||||||||
| Igf2 | ||||||||||
| Krt10 | ||||||||||
| Sprr1b |
Abbreviations: MG-L, mammary gland - lactating; MG-NL, mammary gland - nonlactating; mTEC, medulary thymic epithelial cell; UC, umbilical cord.
a
Data from Ref. 67 were compared to the online gene expression database BioGPS. Genes listed represent those expressed by CD80hi mTEC (vs. CD80lo mTEC) that are restricted in expression to 5 or fewer tissues among more than 60 tissues and cells.
b
Genes included were separated into categories of 3- to 10-fold, 10- to 30-fold and greater than 30-fold above the mean expression across all tissues and cell lines examined.
c
Genes in italic font are regulated independently of Aire.