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Top: TEM images of the inhibition of Aβ42 aggregation by L1 and L2, in the presence or absence of metal ions ([Aβ42] = [M2+] = 25 μM; [compound] = 50 μM; PBS, 37 °C, 24 h, scale bar = 500 nm). Bottom: Native gel electrophoresis/Western blotting analysis. Panels and lanes are as follows: (1) Aβ42; (2) Aβ42 + Cu2+; (3) Aβ42 + Zn2+; (4) Aβ42 + L1; (5) Aβ42 + L1 + Cu2+; (6) Aβ42 + L1 + Zn2+; (7) Aβ42 + L2; (8) Aβ42 + L2 + Cu2+; (9) Aβ42 + L2 + Zn2+; (10) MW marker.
