Table 4. The predicted mean percentages of the subjects with γ-GT elevation and the mean odds ratios (95% CIs) for γ-GT elevation during VPA therapy according to the SOD2 Val16Ala genotype and complication with intellectual disability when different daily doses of VPA were administered to patients without any co-treatment.
Dose (mg) | Intellectualdisability | SOD2 genotype | γ-GTelevation (%) | Odds ratio (95% CIs) |
400 | – | Val/Ala or Ala/Ala | 5.8 | 1 |
– | Val/Val | 13.0 | 2.42 (1.75–3.34) | |
+ | Val/Ala or Ala/Ala | 24.9 | 5.38 (3.98–7.27) | |
+ | Val/Val | 42.4 | 11.91 (8.89–15.98) | |
500 | – | Val/Ala or Ala/Ala | 6.0 | 1 |
– | Val/Val | 14.1 | 2.56 (1.87–3.51) | |
+ | Val/Ala or Ala/Ala | 25.5 | 5.32 (3.95–7.16) | |
+ | Val/Val | 43.8 | 12.12 (9.08–16.17) | |
600 | – | Val/Ala or Ala/Ala | 5.2 | 1 |
– | Val/Val | 16.9 | 3.67 (2.66–5.07) | |
+ | Val/Ala or Ala/Ala | 27.8 | 6.96 (5.10–9.49) | |
+ | Val/Val | 44.8 | 14.68 (10.82–19.91) | |
700 | – | Val/Ala or Ala/Ala | 7.7 | 1 |
– | Val/Val | 17.2 | 2.50 (1.88–3.32) | |
+ | Val/Ala or Ala/Ala | 30.6 | 5.30 (4.05–6.94) | |
+ | Val/Val | 48.1 | 11.17 (8.58–14.54) | |
800 | – | Val/Ala or Ala/Ala | 9.4 | 1 |
– | Val/Val | 20.2 | 2.44 (1.88–3.17) | |
+ | Val/Ala or Ala/Ala | 31.6 | 4.47 (3.48–5.74) | |
+ | Val/Val | 52.6 | 10.74 (8.30–13.75) | |
900 | – | Val/Ala or Ala/Ala | 9.6 | 1 |
– | Val/Val | 21.1 | 2.52 (1.94–3.27) | |
+ | Val/Ala or Ala/Ala | 34.9 | 5.04 (3.94–6.46) | |
+ | Val/Val | 55.6 | 11.77 (9.22–15.03) | |
1000 | – | Val/Ala or Ala/Ala | 10.8 | 1 |
– | Val/Val | 24.2 | 2.65 (2.07–3.39) | |
+ | Val/Ala or Ala/Ala | 35.6 | 4.57 (3.60–5.80) | |
+ | Val/Val | 56.2 | 10.63 (8.40–13.46) | |
1100 | – | Val/Ala or Ala/Ala | 13.1 | 1 |
– | Val/Val | 27.8 | 2.55 (2.02–3.20) | |
+ | Val/Ala or Ala/Ala | 42.6 | 4.90 (3.93–6.13) | |
+ | Val/Val | 57.8 | 9.05 (7.24–11.30) | |
1200 | – | Val/Ala or Ala/Ala | 14.8 | 1 |
– | Val/Val | 28.1 | 2.25 (1.80–2.81) | |
+ | Val/Ala or Ala/Ala | 46.6 | 5.01 (4.04–6.20) | |
+ | Val/Val | 65.3 | 10.83 (8.71–13.46) |
γ-GT: γ-glutamyltransferase; VPA = valproic acid; Dose = daily dose of VPA; SOD2 = superoxide dismutase 2; CIs = confidence intervals; − = absent; + = present.