Figure 1. Cartoon representation of human Angiogenin showing its functional sites and D22G, L35P mutations.

The D22G and L35P mutations in Angiogenin (PDB ID: 1B1I) are labeled and represented as stick models (red). The three key functional sites of human Angiogenin (catalytic triad, nuclear localization signal and receptor binding site) are also shown. The color scheme is as follows - Angiogenin protein: yellow, nuclear localization signal: green, receptor-binding site: violet and catalytic triad of Angiogenin: yellow and blue stick models.