Skip to main content
. 2014 Nov 5;9(11):e111975. doi: 10.1371/journal.pone.0111975

Table 4. E2-responsive networks and associated genes.

Biological process GO term or Pathway Genes
Network 1
Regulation of centrosome cycle Gja1, Plk2
Inactivation of MAPK activity Dusp4, Spred2
Cell-cell junction assembly Gja1, Ugt8a
Regulation of tissue remodeling Gja1, Tfrc
Regulation of mRNA splicing, via spliceosome Gja1, Srrm4
Carbohydrate derivative transport Gja1, Gltp
Regulation of signal transduction by p53 class mediator Gja1, Spred2
Long-term potentiation Gfap, Plk2
Regulation of cell junction assembly Gja1, Tsc1
Lens development in camera-type eye Cryab, Gja1, Tgfrb1
Regulation of phosphoprotein phosphatase activity Nuak1, Tsc1
rRNA transport Gja1, Tsc1, Tst
Network 2
Cerebellum morphogenesis Herc1, Pcnt
Vasoconstriction Apln, Ednrb, Pdgfb
Vasodilation Apln, Cnp, Pdgfb
Network 3
Fatty acid elongation Elovl5, Hadha
Triglyceride biosynthesis Elovl5, Slc25a1
Histone H4 acetylation Mll1, Phf15
Histone H3-K4 methylation Mll1, Tet3
Regulation of ligase activity Mid1ip1, Trib2
Lysine degradation Hadha, Mll1
Negative regulation of protein complex disassembly Gsn, Mid1ip1
Network 4
Response to estradiol stimulus Aqp4, Cryab, Igfbp2
Vasopressin-regulated water reabsorption Adcy9, Aqp4
Network 5
Myelination Fa2h, Pllp, Tsc1, Ugt8a
Network 6
Meiotic chromosome separation Bhlhe40, Top2a
Network 1 and 2
Olfactory lobe development Erbb4, Pcnt
Regulation of phosphatidylinositol 3-kinase activity Erbb4, Pdgfb
Tissue regeneration Erbb4, Gja1
Regulation of lipid kinase activity Erbb4, Pdgfb
Network 2 and 3
Positive regulation of fatty acid metabolic process Irs2, Mid1ip1
Fatty acid beta oxidation Hadha, Irs2
Regulation of polysaccharide metabolic process Irs2, Pdgfb