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. Author manuscript; available in PMC: 2015 Jul 31.
Published in final edited form as: Cell. 2014 Jul 31;158(3):579–592. doi: 10.1016/j.cell.2014.05.051

Figure 2. Nestin expression is associated with poor prognosis and correlates with p53 loss of function in human HCCs.

Figure 2

(A) Nestin mRNA expression in human liver cancer cell lines with intact p53 (p53wt) or loss of p53 function (p53mut/del). (B) Nestin immunohistochemistry of normal liver tissue and HCC tissue. Bars= 50 μm (C) Survival analysis of liver cancer patients stratified into Nestin-positive and Nestin-negative groups. (D) Nestin mRNA expression in human HCCs with p53 loss or diploid p53 status. (E) Co-occurrence of nestin expression and p53 mutation in HCC samples. Fishers exact test was used for measuring association. (F) Nestin expression and p53 expression in a wild-type-p53 expressing (p53 +/+, left panel) and p53 mutant expressing (p53R249S, right panel) tumor nodule of a multinodular HCC. p53 mutation was determined by Sanger sequencing. Bars indicate 50 μm. See also Figure S1.