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. 2014 Nov 5;9(11):e112081. doi: 10.1371/journal.pone.0112081

Figure 3. Heterogeneous sensitivity of hKCa3.1 to the four EETs, stable 14,15-EEZE, 20-HETE and 5,6-DiHETE.

Figure 3

A) Representative traces of hKCa3.1 outward-currents in inside-out patches overtime in the continuing presence of the fatty acids at 10 µM. B) Summary data of maximal change of current (% of control) at two concentrations (1 and 10 µM). 5,6 DiHETE was tested at 10 µM (0±10%, n = 4). C) No KCa3.1-blockade in the presence of anandamide (AEA; 10 µM), arachidonoylglycerol (2-AG; 10 µM), arachidonyl trifluoromethyl ketone (AACOCF3; 10 µM). Numbers in the graphs indicate the number of inside-out experiments. Data are means ± SEM (% inhibition of KCa3.1-current normalized to initial peak amplitude after patch-excision); *P<0.05 vs. vehicle (Ve); One-way ANOVA and Tukey post hoc test.