Figure 4. Evolutionary conservation of transcription factor binding sites in the Nr2f2 5′ flanking region.

Schematic representation of the conservation of the region surrounding the human PRE1 sequence (a) and the human PRE2 sequence (b) compared to corresponding mouse, rat and chimpanzee sequences. a. The well-conserved PRE1 sequence is indicated by asterisks with evolutionarily conserved binding sites for the POU domain transcription factors OCT1 and OCT_C indicated by horizontal bars. Conserved bases are represented by black boxes with mismatches in grey. b. PRE2 is less well conserved with eight mismatched bases and no corresponding POU domain transcription factor binding sites in the TRANSFAC database. Conserved bases are again represented by black boxes with mismatches in grey.