Table 1. Characteristics of colorectal cancer (CRC) cases, adenoma cases, and matched controls, Washington County, MD, 1989-2006.
| Characteristic1 | CRC cases (n=257) |
Controls (n=257) |
p-value | Adenoma cases (n=123) |
Controls (n=123) |
P value |
|---|---|---|---|---|---|---|
|
|
|
|||||
| n (%) | n (%) | n (%) | n (%) | |||
| Age in years [mean (SD)] | 61.8 (11.3) | 61.7 (11.3) | matched | 55.1 (9.7) | 54.9 (9.6) | matched |
| Gender | ||||||
| Female | 140 (54.5) | 140 (54.5) | matched | 62 (50.4) | 62 (50.4) | matched |
| Male | 117 (45.5) | 117 (45.5) | 61 (49.6) | 61 (49.6) | ||
| Cigarette smoking status | ||||||
| Current | 30 (11.7) | 27 (10.5) | 0.35 | 21 (17.1) | 15 (12.2) | 0.08 |
| Former | 100 (38.9) | 85 (33.1) | 52 (42.3) | 41 (33.3) | ||
| Never | 127 (49.4) | 145 (56.4) | 50 (40.7) | 67 (54.5) | ||
| Body mass index (kg/m2) | ||||||
| <25 | 102 (39.7) | 104 (40.5) | 0.51 | 52 (42.3) | 51 (41.5) | 0.71 |
| 25-30 | 103 (40.1) | 110 (42.8) | 49 (39.8) | 54 (43.9) | ||
| 30+ | 52 (20.2) | 43 (16.7) | 22 (17.9) | 18 (14.6) | ||
| Recent hormone use2 | ||||||
| No | 120 (88.2) | 124 (89.2) | 0.85 | 49 (81.7) | 42 (67.7) | 0.13 |
| Yes | 16 (11.8) | 15 (10.8) | 11 (18.3) | 20 (32.3) | ||
| NSAID use 48 hours prior to blood draw | ||||||
| No | 197 (76.7) | 181 (70.4) | 0.11 | 85 (69.1) | 94 (76.4) | 0.18 |
| Yes | 60 (23.3) | 76 (29.6) | 38 (30.9) | 29 (23.6) | ||
| Family history of CRC | ||||||
| No | 124 (78.0) | 150 (86.7) | 0.03 | 86 (71.7) | 98 (83.8) | 0.11 |
| Yes | 35 (22.0) | 23 (13.3) | 34 (28.3) | 19 (16.2) | ||
1
all characteristics were ascertained at baseline in 1989, with the exception of family history (1996) and frequency of NSAID use (1996, 1998, 2000, 2003), both ascertained through follow-up questionnaires
2
ascertained for women only