Table 3. Associations between JCV T-antigen (T-Ag) seroreactivity, colorectal cancer (CRC), and colorectal adenomas, Washington County, MD, 1989-2006.
| Subgroup | JCV T-Ag Seroreactivity1 | CRC cases | Controls | Adenoma cases | Controls | ||
|---|---|---|---|---|---|---|---|
|
| |||||||
| n (%) | n (%) | OR (95% CI)2 | n (%) | n (%) | OR (95% CI)2 | ||
| Overall | Low | 115 (44.7) | 126 (49.0) | 1.00 (reference) | 61 (49.6) | 65 (52.8) | 1.00 (reference) |
| High | 142 (55.3) | 131 (51.0) | 1.34 (0.89-2.01) | 62 (50.4) | 58 (47.2) | 1.30 (0.70-2.42) | |
| Gender: | |||||||
| Male | Low | 43 (36.8) | 40 (34.2) | 1.00 (reference) | 26 (42.6) | 30 (49.2) | 1.00 (reference) |
| High | 74 (63.2) | 77 (65.8) | 0.93 (0.51-1.67) | 35 (57.4) | 31 (50.8) | 1.29 (0.55-2.98) | |
| Female | Low | 72 (51.4) | 86 (61.4) | 1.00 (reference) | 35 (56.5) | 35 (56.5) | 1.00 (reference) |
| High | 68 (48.6) | 54 (38.6) | 1.82 (1.00-3.31) | 27 (43.5) | 27 (43.5) | 1.21 (0.45-3.28) | |
| Anatomic site: | |||||||
| Distal | Low | 31 (44.3) | 33 (47.1) | 1.00 (reference) | 42 (60.9) | 39 (56.5) | 1.00 (reference) |
| colon | High | 39 (55.7) | 37 (52.9) | 1.35 (0.61-2.99) | 27 (39.1) | 30 (43.5) | 0.77 (0.31-1.93) |
| Proximal | Low | 51 (45.9) | 54 (48.6) | 1.00 (reference) | 20 (37.0) | 29 (53.7) | 1.00 (reference) |
| colon | High | 60 (54.1) | 57 (51.4) | 1.30 (0.68-2.48) | 34 (63.0) | 25 (46.3) | 2.85 (0.89-9.15) |
| Rectum | Low | 29 (45.3) | 35 (54.7) | 1.00 (reference) | 15 (57.7) | 10 (38.5) | 1.00 (reference) |
| High | 35 (54.7) | 29 (45.3) | 1.93 (0.81-4.60) | 11 (42.3) | 16 (61.5) | 0.24 (0.03-1.60) | |
| Stage at diagnosis | |||||||
| Local | Low | 71 (45.8) | 73 (47.1) | 1.00 (reference) | NA | NA | NA |
| High | 84 (54.2) | 82 (52.9) | 1.13 (0.67-1.92) | ||||
| Regional | Low | 24 (42.1) | 26 (45.6) | 1.00 (reference) | NA | NA | NA |
| High | 33 (57.9) | 31 (54.4) | 1.38 (0.56-3.40) | ||||
| Distant | Low | 17 (48.6) | 22 (62.9) | 1.00 (reference) | NA | NA | NA |
| High | 18 (51.4) | 13 (37.1) | 3.84 (0.50-29.30) | ||||
| Adenoma size | |||||||
| <0.55 cm | Low | NA | NA | NA | 22 (45.8) | 25 (52.1) | 1.00 (reference) |
| High | 26 (54.2) | 23 (47.9) | 1.71 (0.56-5.16) | ||||
| >=0.55 cm | Low | NA | NA | NA | 28 (58.3) | 29 (60.4) | 1.00 (reference) |
| High | 20 (41.7) | 19 (39.6) | 1.53 (0.61-3.80) | ||||
NA= not applicable.
1
Low versus high based on the median seroreactivity level among all controls combined.
2
Odds ratios (OR) and 95% confidence intervals (CI) adjusted for smoking status, body mass index, and family history of CRC.
Note: matching factors included age, gender, race and date of blood draw.