. Author manuscript; available in PMC: 2015 Nov 1.

Published in final edited form as: Cancer Epidemiol Biomarkers Prev. 2014 Aug 8;23(11):2393–2403. doi: 10.1158/1055-9965.EPI-14-0384

Table 3.

Relationship between the biomarkers and correlates of esophageal adenocarcinoma (n = 411)

	CRP	IL6	sTNF-RI	sTNF-RII	Isoprostanes

Age^a	0.08	0.18^*	0.37^*	0.43^*	−0.03
Waist Hip Ratio^a	0.10^*	0.08	0.13^*	0.08	−0.12^*
Cigarette pack years^b	0.24^*	0.22^*	0.22^*	0.12^*	0.07
NSAID use^c	−0.15	0.21	0.01	0.04	−0.06
CRP^a	-	0.44^*	0.18^*	0.20^*	0.22^*
IL-6^a	-	-	0.21^*	0.26^*	0.08
sTNF-RI^a	-	-	-	0.63^*	0.12^*
sTNF-RII^a	-	-	-	-	0.14^*
Isoprostanes^a	-	-	-	-	-

p-value < 0.05

Pearson’s correlation coefficient

Spearman correlation coefficient

Difference in biomarker (β coefficient) between current users and non-current users of NSAIDs

Non-smokers coded as have smoked zero pack-years

NSAID = Non-steroidal anti-inflammatory drugs, NSAIDs coded Non-current vs. current

CRP = C-reactive protein, IL6 = Interleukin 6, sTNF-RI & II = soluble tumor necrosis factor receptor I & I