Skip to main content
. Author manuscript; available in PMC: 2015 Nov 1.
Published in final edited form as: Expert Rev Anticancer Ther. 2014 Jun 13;14(11):1369–1378. doi: 10.1586/14737140.2014.928594

Table 1. Proposed mechanisms of acquired resistance to novel agents.

Mechanism Reference
Increased intratumoral androgen production [24-26]
Androgen receptor point mutation F876L [30,32,33]
Androgen receptor splice variants [24,41,47]
Glucocorticoid receptor bypassing androgen receptor [50]