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. 2014 Nov 5;9(11):e111976. doi: 10.1371/journal.pone.0111976

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© 2014 Nair et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Representative images of the renal pathology of rats from all experimental groups as assessed by Masson’s trichrome staining of the kidney sections (n = 6). There are no significant renal structural changes visible in LZRCC and LZRBB groups. However, renal changes in the OZRCC image are evident in glomeruli, tubules and interstitium. There is moderate glomerular fibrosis; tubular dilatation and attenuation of lining epithelium with intraluminal hyaline casts; tubular atrophy; multifocal to coalescing moderate to severe interstitial fibrosis; multifocal interstitial, moderate to severe lymphocytic and plasmacytic nephritis. OZRBB animals exhibited less pathological changes with minimal interstitial fibrosis.