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. Author manuscript; available in PMC: 2015 Nov 1.
Published in final edited form as: Cancer Immunol Res. 2014 Jul 30;2(11):1080–1089. doi: 10.1158/2326-6066.CIR-14-0095

Figure 4.

Figure 4

PI3K-Akt signaling inhibition mitigates tumor growth.
  1. TC-1 tumor-bearing mice were treated with WM or DMSO for one week after palpable tumors were detected. Mice were then vaccinated with E7 peptide and tumor growth was monitored. Both E7 vaccination (p<0.05) and WM treatment (p<0.001) significantly inhibited TC-1 tumor growth, yet the greatest impairment was achieved with the combination of WM treatment and E7 vaccination (p<0.0001).
  2. Mice were prophylactically treated with WM, TCN or DMSO prior to s.c. B16 tumor inoculation and tumor growth was monitored. Tumor growth was significantly inhibited by WM and TCN compared to DMSO-treated animals (p<0.0001).