. Author manuscript; available in PMC: 2015 Nov 30.

Published in final edited form as: Stat Med. 2014 Jul 20;33(27):4715–4733. doi: 10.1002/sim.6269

Table 5.

Estimates for the survival components of SPMs with K = 2

	Longitudinal Symptom	α*		α ₁		β ₁		β ₂		β ₃
Model	Longitudinal Symptom	HR	P-value	HR	P-value	HR	P-value	HR	P-value	HR	P-value
SPML	Anorexia	0.628	<.0001	0.604	<.0001	1.403	<.0001	2.850	0.0024
	Cough	0.646	<.0001	0.643	<.0001	1.209	0.0080	1.722	0.0892
	Dyspnea	0.654	<.0001	0.666	0.0001	1.218	0.0043	3.560	<.0001
	Fatigue	0.635	<.0001	0.632	<.0001	1.418	<.0001	3.539	0.0003
	Pain	0.645	<.0001	0.669	0.0002	1.380	<.0001	5.331	<.0001

SPMQ	Anorexia	0.622	<.0001	0.597	<.0001	1.512	<.0001	3.087	0.0439	152.189	0.1499
	Cough	0.638	<.0001	0.632	<.0001	1.271	0.0054	1.811	0.0940	12.470	0.1317
	Dyspnea	0.646	<.0001	0.661	<.0001	1.228	0.0053	2.896	0.0093	44.221	0.0688
	Fatigue	0.620	<.0001	0.619	<.0001	1.446	<.0001	2.275	0.0873	9.179	0.4013
	Pain	0.645	<.0001	0.662	<.0001	1.403	<.0001	4.293	<.0001	144.619	0.0035

SPMQL	Anorexia	0.618	<.0001	0.599	<.0001	1.382	0.0001	1.382	0.0378
	Cough	0.632	<.0001	0.628	<.0001	1.178	0.0193	1.087	0.4370
	Dyspnea	0.637	<.0001	0.649	<.0001	1.176	0.0203	1.416	0.0058
	Fatigue	0.614	<.0001	0.612	<.0001	1.407	<.0001	1.542	0.0018
	Pain	0.638	<.0001	0.652	<.0001	1.308	0.0001	1.618	<.0001

When fitting the PFS data alone using (3.6), the HR for the treatment effect is 0.647 with p-value <.0001.