TABLE 1.
Baseline Patient Characteristics
| Characteristic | Gabapentin (n = 207) | Placebo (n = 206) | P |
|---|---|---|---|
| Age group | |||
| ≥50 | 150 (73%) | 148 (72%) | .89 |
| Sex | |||
| Female | 145 (70%) | 145 (70%) | .94 |
| Dominant disease status | .77 | ||
| Breast | 117 (57%) | 116 (57%) | |
| Lung | 30 (15%) | 35 (17%) | |
| Colorectal | 1 (1%) | 0 (0%) | |
| Gynecologic | 1 (1%) | 0 (0%) | |
| Hematologic | 5 (2%) | 4 (2%) | |
| Other | 52 (25%) | 50 (24%) | |
| Chemotherapy | .81 | ||
| Cisplatin-based | 79 (38%) | 81 (39%) | |
| Use of palonosetron on day 1 | .95 | ||
| Yes | 121 (59%) | 121 (59%) | |
| Use of 5HT3 antagonist after day 1 | .89 | ||
| Yes | 74 (36%) | 75 (36%) | |
| Number of emetic agents high | 1.00 | ||
| 1–2 | 202 (99%) | 201 (99%) | |
| 3–4 | 3 (2%) | 3 (2%) | |
| Number of emetic agents moderate | .31 | ||
| 0 | 146 (75%) | 151 (80%) | |
| 1–2 | 49 (25%) | 38 (20%) | |
| 3–4 | 1 (1%) | 0 (0%) | |
| History of alcoholism | .71 | ||
| No | 192 (93%) | 193 (94%) | |
| History of motion sickness/pregnancy-induced emesis | .94 | ||
| No | 140 (68%) | 140 (68%) | |