Table 3. Dietary Inflammatory Index (DII) from food and supplements and colorectal cancer risk; IWHS, 1986-2010.
| # cases | HRa, 95% CI | HRb, 95% CI | # cases | HRa, 95% CI | HRb, 95% CI | # cases | HRa, 95% CI | HRb, 95% CI | |
|---|---|---|---|---|---|---|---|---|---|
| Colorectal cancer | Colon cancer | Rectal cancer | |||||||
| DII continuous | 1636 | 1.09 (1.03, 1.14) | 1.07 (1.01, 1.13) | 1329 | 1.08 (1.02, 1.13) | 1.05 (0.99, 1.12) | 325 | 1.10 (0.99, 1.23) | 1.11 (0.98, 1.25) |
| DII quintiles | |||||||||
| Quintile 1 | 290 | 1 (referent) | 1 (referent) | 236 | 1 (referent) | 1 (referent) | 58 | 1 (referent) | 1 (referent) |
| Quintile 2 | 318 | 1.11 (0.94, 1.30) | 1.04 (0.89, 1.22) | 267 | 1.14 (0.96, 1.34) | 1.07 (0.89, 1.28) | 54 | 0.93 (0.64, 1.35) | 0.91 (0.62, 1.32) |
| Quintile 3 | 335 | 1.18 (1.01, 1.38) | 1.11 (0.95, 1.31) | 270 | 1.17 (0.98, 1.40) | 1.10 (0.92, 1.31) | 73 | 1.28 (0.91, 1.81) | 1.23 (0.86, 1.76) |
| Quintile 4 | 341 | 1.20 (1.03, 1.40) | 1.13 (0.95, 1.33) | 270 | 1.17 (0.98, 1.39) | 1.08 (0.89, 1.29) | 71 | 1.24 (0.88, 1.76) | 1.25 (0.87, 1.80) |
| Quintile 5 | 352 | 1.29 (1.10, 1.51) | 1.20 (1.01, 1.43) | 286 | 1.28 (1.08, 1.53) | 1.19 (0.98, 1.45) | 69 | 1.25 (0.88, 1.77) | 1.21 (0.81, 1.79) |
| P-trend | 0.001 | 0.03 | 0.008 | 0.10 | 0.09 | 0.16 | |||
a
Age-adjusted
b
Adjusted for age, BMI, smoking status, pack-years of smoking, HRT use, education, diabetes, and total energy intake.