Table 3.
Indentification of putative HREs in genes related to stress response, steroidogenesis, immunity and cell growth.
| Gene name or symbol | Accession | HREs | Location relative to TSS | Strand | p-value |
|---|---|---|---|---|---|
| CRH | NM_000756 | 3 | + 260 | forward | <.001 |
| + 280 | forward | <.001 | |||
| + 338 | forward | <.001 | |||
| CRHR1 | NM_004382 | 0 | NA | NA | NA |
| POMC | NM_000939 | 2 | − 248 | reverse | NS |
| + 382 | reverse | NS | |||
| PCSK1 | NM_000439 | 2 | − 1582 | forward | <.005 |
| − 1294 | reverse | NS | |||
| PCSK2 | NM_002594 | 2 | − 1292 | forward | <.05 |
| − 1287 | forward | <.005 | |||
| MC2R | NM_000529 | 2 | − 1530 | forward | <.05 |
| − 829 | reverse | <.05 | |||
| NQO2 | NM_000904 | 0 | NA | NA | NA |
| TGFB1 | 000660 | 2 | − 936 | forward | NS |
| − 133 | reverse | NS | |||
| TGFB2 | NM_003238 | 5 | − 790 | reverse | <.001 |
| − 767 | reverse | <.001 | |||
| − 466 | reverse | <.001 | |||
| − 762 | forward | <.05 | |||
| + 42 | forward | <.05 | |||
| CYP11A1 | NM_000781 | 0 | NA | NA | NA |
| CYP11B1 | NM_000497 | 1 | − 75 | reverse | NS |
| HSD3B1 | NM_000862 | 0 | NA | NA | NA |
| CYP17A1 | NM_000102 | 0 | NA | NA | NA |
| CYP21A2 | NM_000500 | 0 | NA | NA | NA |
| HSD11B1 | NM_005525 | 0 | NA | NA | NA |
| HSD11B2 | NM_000196 | 0 | NA | NA | NA |
| DHCR7 | NM_001360 | 5 | − 901 | forward | <.05 |
| − 760 | forward | <.05 | |||
| − 637 | forward | <.05 | |||
| − 622 | forward | <.005 | |||
| − 251 | forward | <.001 | |||
| IL1A | NM_000575 | 0 | NA | NA | NA |
| IL1B | NM_000576 | 2 | − 1123 | forward | NS |
| − 296 | forward | <.05 | |||
| IL5 | NM_000879 | 0 | NA | NA | NA |
| IL10 | NM_000572 | 0 | NA | NA | NA |
| IL17A | NM_002190 | 0 | NA | NA | NA |
| PDGFA | NM_002607 | 5 | − 1972 | reverse | <.05 |
| − 1549 | reverse | <.05 | |||
| − 1432 | forward | <.05 | |||
| − 1401 | forward | <.005 | |||
| − 574 | forward | <.005 | |||
| TFRC | NM_003234 | 3 | − 1112 | forward | <.05 |
| − 327 | reverse | NS | |||
| − 19 | forward | <.05 | |||
| IFNA1 | NM_024013 | 0 | NA | NA | NA |
| IFNB1 | NM_024013 | 0 | NA | NA | NA |
| TGFA | NM_003236 | 0 | NA | NA | NA |
| EGFR | NM_005228 | 0 | NA | NA | NA |
| CCL5 | NM_002985 | 2 | + 32 | forward | NS |
| + 468 | forward | NS | |||
| NPL | NM_030769 | 0 | NA | NA | NA |
The promoter regions of a panel of genes involved in melanogensis were scanned for the presence of putative HIF binding sites (HREs) as described in the methods. A summary of each genes profile, its accession number at the National Center for Biotechnology Information (NCBI), and the identified putative HRE locations are listed; NA-not applicable (no binding sites identified), NS-not significant.