Fig. 2.

Soluble VEGFR-3 selectively inhibits inflammatory lymphangiogenesis induced by penetrating keratoplasty. a Representative micrographs show the effect of sVEGFR-3 on corneal hem- and lymphangiogenesis after allotransplantation. Corneal flat mounts were prepared 2 weeks after transplantation and immunohistochemically stained for CD31 (blood vessels, green) and LYVE-1 (lymphatic vessels, red). b Percent area invaded by blood (CD31⁺, p=0.3) or lymphatic (LYVE-1⁺, p=0.01) vessels was measured and Student’s t test was used for statistical analysis; error bars indicate ± SEM (n=5 eyes/group). Data from one of two experiments are shown