Table 3.

Significant miRNA SNPs (P<0.01) in the Late-Stage Survival Analysis (Discovery Set)

SNP	CHR	Position (bp, Hg19)	Genotype	Death N (%)	Censored N (%)	Median Survival Time (Months)	Comparison	Unadjusted Model		Adjusted Model		FDR q	MicroRNA
								HR & 95% CI	P	HR & 95% CI	P
rs17111728	1	55691384	TT	372(83.22%)	75(16.78%)	13.9		1.00 (reference)		1.00 (reference)			hsa-mir-4422
			TC	48(76.19%)	15(23.81%)	22.3	1 vs 0	0.74(0.55~1.01)	5.71E-02	0.63(0.46~0.86)	3.87E-03
			CC	2(40%)	3(60%)	-	2 vs 0	0.36(0.09~1.43)	1.45E-01	0.25(0.06~1.01)	5.20E-02
							Additive	0.71(0.54~0.94)	1.72E-02	0.60(0.45~0.8)	4.79E-04	5.31E-2
rs2042253	5	143059433	TT	223(83.52%)	44(16.48%)	13.5		1.00 (reference)		1.00 (reference)			hsa-mir-5197
			TC	159(84.13%)	30(15.87%)	16.1	1 vs 0	0.88(0.72~1.09)	2.47E-01	0.79(0.64~0.97)	2.43E-02
			CC	22(73.33%)	8(26.67%)	23.4	2 vs 0	0.72(0.46~1.11)	1.40E-01	0.65(0.42~1.01)	5.44E-02
							Additive	0.87(0.74~1.02)	8.70E-02	0.79(0.67~0.94)	6.95E-03	1.93E-1
rs550894	11	6521940	CC	339(83.91%)	65(16.09%)	14.8		1.00 (reference)		1.00 (reference)			hsa-mir-612
			AC	69(74.19%)	24(25.81%)	20.1	1 vs 0	0.75(0.58~0.98)	3.31E-02	0.74(0.57~0.97)	2.88E-02
			AA	3(50%)	3(50%)	25.2	2 vs 0	0.40(0.13~1.25)	1.16E-01	0.30(0.09~0.95)	4.03E-02
							Additive	0.73(0.57~0.92)	9.05E-03	0.70(0.55~0.89)	2.98E-03	1.15E-1
rs7227168	18	20513374	CC	320(80.6%)	77(19.4%)	16.4		1.00 (reference)		1(reference)			hsa-mir-4741
			TC	89(85.58%)	15(14.42%)	10.1	1 vs 0	1.38(1.09~1.76)	8.49E-03	1.49(1.17~1.91)	1.44E-03
			TT	9(100%)	0(0%)	11.9	2 vs 0	1.69(0.87~3.28)	1.23E-01	1.31(0.66~2.6)	4.43E-01
							Additive	1.35(1.11~1.65)	3.16E-03	1.35(1.11~1.65)	3.11E-03	1.15E-1