Table 2.

Ovarian-Cancer Specific Mortality by Relative Telomere Length z Score Quartiles Among Ovarian Cancer Patients.

Relative TL z score	Reference Modela HRb (95%CI)	P	Multivariate Model HRc (95%CI)	P
Quartile 1	1.00 (ref)		1.00 (ref)
Quartile 2	0.79 (0.60–1.02)	0.07	0.80 (0.60–1.05)	0.11
Quartile 3	0.90 (0.69–1.17)	0.43	0.94 (0.71–1.25)	0.66
Quartile 4	0.88 (0.67–1.07)	0.35	0.92 (0.69–1.23)	0.57
Quartile 2+3+4	0.85 (0.69–1.05)	0.13	0.88 (0.77–1.10)	0.25
P – trend	0.97 (0.89–1.06)	0.55	0.99 (0.90–1.09)	0.83
Serous tumors
Quartile 1	1.00 (ref)		1.00 (ref)
Quartile 2	0.90 (0.67–1.23)	0.50	0.88 (0.63–1.23)	0.47
Quartile 3	0.86 (0.63–1.18)	0.36	0.84 (0.60–1.17)	0.29
Quartile 4	0.88 (0.64–1.20)	0.42	0.87 (0.62–1.22)	0.41
Quartile 2+3+4	0.88 (0.68–1.14)	0.33	0.86 (0.66–1.13)	0.28
P – trend	0.96 (0.88–1.06)	0.40	0.95 (0.85–1.06)	0.38
Non-serous tumors
Quartile 1	1.00 (ref)		1.00 (ref)
Quartile 2	0.89 (0.53–1.51)	0.67	0.97 (0.55–1.70)	0.91
Quartile 3	1.19 (0.71–1.98)	0.51	1.33 (0.76–2.33)	0.32
Quartile 4	0.98 (0.56–1.70)	0.94	1.13 (0.63–2.03)	0.67
Quartile 2+3+4	1.01 (0.66–1.55)	0.96	1.13 (0.71–1.79)	0.62
P – trend	1.03 (0.86–1.22)	0.77	1.04 (0.45–2.41)	0.92

^aReference HR adjusted for age at blood (continuous), batch (batch 1, batch 2) and stage (I, II, III, IV).

^bHR = hazard ratio; CI = confidence interval.

^cMultivariate HR adjusted for adjusted for age at blood (continuous), batch (batch 1, batch 2), stage (I, II, III, IV), age at diagnosis (continuous), BRCA mutation status (carrier/non-carrier), histologic subtype (serous, mucinous, endometrioid, other), BMI five years prior to the cancer diagnosis (continuous), smoking history (ever/never) and chemotherapy (yes/no).