Table 3.
Neurologic symptom | Variable | Effect | Odds ratio | 95 % Confidence interval | p value | |
---|---|---|---|---|---|---|
Dizziness | Gender | Female vs. male | 2.01 | 1.01 | 4.0 | 0.05 |
H/O leukemia relapse | Yes vs. no | 4.81 | 1.02 | 22.71 | 0.05 | |
Fatigue | H/O leukemia relapse | Yes vs. no | 8.35 | 1.16 | 59.93 | 0.03 |
Urine incontinence | Gender | Female vs. male | 4.49 | 1.64 | 12.26 | <0.0001 |
Age at Dx | Older vs. younger | 0.84 | 0.71 | 0.99 | 0.04 | |
IT-chemotherapya | ≥10 vs. <10 doses | 3.61 | 1.31 | 9.95 | 0.01 | |
Constipation | Gender | Female vs. male | 2.33 | 1.05 | 5.16 | 0.04 |
Seizure | CNS cancer | Yes vs. no | 3.03 | 1.05 | 8.73 | 0.04 |
Ataxia | Radiation | Yes vs. no | 4.78 | 1.64 | 13.93 | <0.0001 |
Back pain | IT-chemotherapya | ≥10 vs. <10 doses | 0.44 | 0.2 | 0.96 | 0.04 |
Neuropathy | Gender | Female vs. male | 2.23 | 1.12 | 4.41 | 0.02 |
IT-chemotherapya | ≥10 vs. <10 doses | 2.0 | 1.02 | 3.93 | 0.04 |
vs. versus, Dx ALL diagnosis, IT intrathecal
All participants received triple intrathecal therapy with cytarabine, methotrexate, and hydrocortisone