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. Author manuscript; available in PMC: 2014 Nov 6.
Published in final edited form as: Nature. 2012 Aug 2;488(7409):111–115. doi: 10.1038/nature11362

Figure 2. Transcriptomic effects of ASOs.

Figure 2

Microarray analysis of gene expression in quadriceps muscle (n = 4 mice per group). a, Principle component analysis shows segregation of HSALR (saline) away from wild-type mice in widely separated clusters. ASOs caused HSALR transgenic mice to cluster nearer to wild-type mice (25 mg/kg biweekly for 4 wks). b, Among transcripts upregulated in HSALR vs. wild-type mice (saline), > 85% showed complete or partial return to normal expression after treatment with ASOs.