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. Author manuscript; available in PMC: 2015 Oct 2.
Published in final edited form as: Oncogene. 2014 May 5;34(14):1811–1821. doi: 10.1038/onc.2014.116

Figure 6.

Figure 6

Talin S425 phosphorylation in stages of human PCa. (a) Immunohistochemical staining of talin S425 phosphorylation in primary tumor, lymph node metastases and bone metastases. Arrows indicate atrophied glands, and an arrow head indicates normal glands in primary tumor. Scale bar represents 100 μm. (b) Percentage of human specimens expressing talin S425 phosphorylation. *P < 0.005 and **P < 0.05. (c) Model of β1 integrin activation by talin1 S425 phosphorylation in metastatic PCa cells. (1) Overexpression of p35 increases Cdk5 activity in tumor cells of high metastatic potential, increasing phosphorylation of talin1 on S425, which induces a conformational change leading to talin1 activation. Binding of additional proteins may facilitate this conformational change. (2) Phosphorylated talin1 binds to the cytoplasmic tail of β1 integrin and (3) increases β1 integrin activation and (4) promotes integrin signaling, leading to increased survival, adhesion, motility and metastatic potential of PCa cells.