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A498 cells were treated with NPRL-Z-1 or etoposide for 30 min and the ICE assay was performed to detect TOP2–DNA adduct formation as described in Materials and Methods. TOP2-free form was partitioned into fractions between 1 and 4. TOP2αcc (A) and TOP2βcc (B) were trapped between fractions 5 and 8, respectively.
