Table 1. Participant characteristics by attempting pregnancy after cancer in a cohort of female adolescent and young adult survivors (N=251).
| Participant Characteristics | Overall | Pregnancy Attempt N=52 | No Pregnancy Attempt N=199 | P valuea |
|---|---|---|---|---|
| N (%) | N (%) | N (%) | ||
| Demographics | ||||
| Age at Study Enrollment, years | <0.01 | |||
| Mean [SD] | 31.3 [5.6] | 33.8 [4.7] | 30.6 [5.6] | |
| 19 to 25 | 47 (18.8) | 3 (5.8) | 44 (22.2) | |
| 26 to 31 | 86 (34.4) | 14 (26.9) | 72 (36.4) | |
| 32 to 37 | 85 (34.0) | 25 (48.1) | 60 (30.3) | |
| 38 to 44 | 32 (12.8) | 10 (19.2) | 22 (11.1) | |
| Race | 0.63 | |||
| White | 198 (79.2) | 39 (75.0) | 159 (80.3) | |
| Black | 8 (3.2) | 1 (1.9) | 7 (3.5) | |
| Asian | 13 (5.2) | 3 (5.8) | 10 (5.1) | |
| Other | 31 (12.4) | 9 (17.3) | 22 (11.1) | |
| Body Mass Index (kg/m2) | 0.59 | |||
| < 25 | 146 (58.2) | 27 (51.9) | 119 (59.8) | |
| 25 – 29.9 | 58 (23.1) | 14 (26.9) | 44 (22.1) | |
| ≥ 30 | 47 (18.7) | 11 (21.2) | 36 (18.1) | |
| Education | 0.82 | |||
| College graduate | 214 (86.3) | 46 (88.5) | 168 (85.7) | |
| Did not graduate from college | 34 (13.7) | 6 (11.5) | 28 (14.3) | |
| Income | <0.01 | |||
| ≤ $50,000 | 80 (31.9) | 6 (11.5) | 74 (37.2) | |
| > $50,000 | 120 (47.8) | 37 (71.2) | 83 (41.7) | |
| Declined to answer | 51 (20.3) | 9 (17.3) | 42 (21.1) | |
| Current Smoker | 6 (2.4) | 2 (3.9) | 4 (2.0) | 0.61 |
| Comorbid Medical Conditionsb | 1.00 | |||
| 0 | 89 (35.5) | 18 (34.6) | 71 (35.7) | |
| 1 or more | 162 (64.5) | 34 (65.4) | 128 (64.3) | |
| Reproductive Characteristics | ||||
| Relationship Status | <0.01 | |||
| Partnered | 143 (57.0) | 48 (92.3) | 95 (47.7) | |
| Not partnered | 108 (43.0) | 4 (7.7) | 104 (52.3) | |
| Live Birth Before Cancer Diagnosis | 41 (16.3) | 12 (23.1) | 29 (14.6) | 0.15 |
| Desire to Have a Baby in the Future | 220 (87.6) | 43 (91.5) | 177 (100.0) | <0.01 |
| Cancer & Treatment Characteristics | ||||
| Cancer Diagnosis | 0.21 | |||
| Breast | 81 (32.3) | 17 (32.7) | 64 (32.2) | |
| Lymphoma | 69 (27.5) | 12 (23.1) | 57 (28.7) | |
| Blood/Leukemia | 19 (7.6) | 4 (7.7) | 15 (7.5) | |
| Thyroid | 14 (5.5) | 7 (13.5) | 7 (3.5) | |
| Gynecologic (cervix/uterus/ovary) | 13 (5.2) | 2 (3.8) | 11 (5.5) | |
| Other | 55 (21.9) | 10 (19.2) | 45 (22.6) | |
| Cancer Stage | 0.16 | |||
| I | 53 (21.5) | 11 (21.6) | 42 (21.5) | |
| II | 76 (30.9) | 17 (33.3) | 59 (30.3) | |
| III | 45 (18.3) | 6 (11.7) | 39 (20.0) | |
| IV | 18 (7.3) | 1 (2.0) | 17 (8.7) | |
| Unknown | 54 (22.0) | 16 (31.4) | 38 (19.5) | |
| Time Since Cancer Diagnosis | <0.01 | |||
| Median [IQR], years | 2.4 [4.0] | 5.0 [7.1] | 2.1 [3.3] | |
| ≤ 2 years | 108 (43.0) | 11 (21.2) | 97 (48.7) | |
| > 2 years | 143 (57.0) | 41 (78.8) | 102 (51.3) | |
| Surgery | 151 (60.2) | 35 (67.3) | 116 (58.3) | 0.27 |
| Chemotherapy | 204 (81.3) | 38 (73.1) | 166 (83.4) | 0.11 |
| Radiation Therapy | 127 (50.6) | 28 (53.9) | 99 (49.8) | 0.64 |
| Endocrine Therapy | 48 (19.1) | 11 (21.2) | 37 (18.6) | 0.69 |
| Bone Marrow or Stem Cell Transplant | 15 (6.0) | 0 (0.0) | 15 (7.5) | 0.05 |
Note: Due to missing data, some variables do not add up to 251.
a
Fisher's exact tests were used for categorical variables, and Student's t-tests were performed for continuous variables.
b
Comorbid medical conditions included asthma/lung disease, high blood pressure, diabetes/high blood sugar, being overweight (obesity), overactive/underactive thyroid, depression/bipolar disorder, eating disorder, rheumatologic diseases, Crohn's disease/ulcerative colitis, seizures/neurologic disorders, TIA/stroke.