Table 3.
List of the differentially expressed genes (DEGs) involved in the pathophysiology of the EPC response to SVCV infection
| Abbr. | Gene description | *Fold changes | *Fold changes | *Fold changes |
|---|---|---|---|---|
| (3 h, Log2) | (6 h, Log2) | (24 h Log2) | ||
| Oxidative stress in SVCV infection | ||||
| NDUFA12 | NADH dehydrogenase 1 alpha subcomplex 12 | - | - | −1.36 |
| NDUFA1 | NADH dehydrogenase 1 alpha subcomplex 1 | - | - | −1.76 |
| NDUFA11 | NADH dehydrogenase 1 alpha subcomplex subunit 11 | −0.84 | −1.01 | −1.38 |
| NDUFA7 | NADH dehydrogenase 1 alpha subcomplex 7 | - | - | −1.98 |
| UQCRFS1 | Ubiquinol-cytochrome c reductase iron-sulfur subunit | - | - | −2.51 |
| ATPeVPL | Vacuolar ATP synthase 16 kDa proteolipid subunit | - | - | −1.22 |
| NDUFS5 | NADH dehydrogenase Fe-S protein 5 | - | - | −1.11 |
| COX7B | cytochrome c oxidase subunit VIIb | - | - | −1.25 |
| SOD1 | Cu/Zn-superoxide dismutase | - | - | −1.15 |
| SESN | Sestrin-3 | −1.61 | −0.72 | 2.76 |
| Cyb5a | Cyb5a protein | - | - | −3.06 |
| ENC1 | Ectodermal-neural cortex 1, a member of the kelch-related family of actin-binding proteins | 1.30 | - | −1.14 |
| OSGIN1 | Oxidative stress-induced growth inhibitor 1 | - | - | 1.39 |
| UCP2 | Mitochondrial uncoupling protein 2, control of mitochondria-derived reactive oxygen species | - | - | 1.16 |
| HSP90 | Heat shock protein HSP 90-alpha | −1.88 | −1.61 | 1.50 |
| C/EBP beta | CCAAT/enhancer binding protein beta | 0.98 | - | 2.96 |
| GADD45A | Growth arrest and DNA-damage-inducible, alpha, a | −0.98 | - | 3.38 |
| GADD45B | Growth arrest and DNA-damage-inducible, beta b | 1.92 | 1.01 | 4.43 |
| Jun-B | Transcription factor jun-B | 1.73 | 2.14 | 4.43 |
| Apoptosis induced by SVCV infection | ||||
| NFKBIA | NF-kappaB inhibitor alpha-like protein A | - | - | 3.41 |
| NFKBIB | NF-kappaB inhibitor alpha-like protein B | - | - | 5.32 |
| CSRNP1 | Cysteine/serine-rich nuclear protein 1-like | 1.17 | 0.69 | 3.99 |
| CASP8 | Caspase 8 | - | - | 1.35 |
| TNFRSF1A | Tumor necrosis factor receptor superfamily member 1A precursor | - | - | 1.09 |
| BIRC2-3 | Baculoviral IAP repeat-containing 3 | 0.90 | - | 1.43 |
| MYD88 | Myeloid differentiation primary response protein MyD88 | 1.45 | - | 2.02 |
| GADD45A | Growth arrest and DNA-damage-inducible, alpha, a | −0.98 | - | 3.38 |
| GADD45B | Growth arrest and DNA-damage-inducible, beta b | 1.92 | 1.01 | 4.43 |
| OSGIN1 | Oxidative stress-induced growth inhibitor 1 | - | - | 1.39 |
| YWHAE | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 2 ,14-3-3 protein epsilon | - | - | −1.02 |
| Gelsolin | Scinderin like b | - | - | −1.34 |
| Mdm2 | E3 ubiquitin-protein ligase | - | - | 2.12 |
| PDCD6 | Programmed cell death protein 6 | 1.50 | 0.93 | 1.79 |
| DDIT3 | DNA damage-inducible transcript 3 protein | - | - | 3.57 |
| IRF7 | IFN-regulatory factory 7 | - | - | 3.59 |
| PIM1 | Proto-oncogene serine/threonine-protein kinase pim-1 | 1.70 | 1.60 | 2.58 |
| BBC3 | BCL2 binding component 3 | - | - | 5.37 |
| JUN-D | Transcription factor jun-D | - | - | 5.45 |
| Tax1bp1 | Tax1-binding protein 1 homolog B | - | - | 2.35 |
| PHLDA3 | Pleckstrin homology-like domain family B member 3-like | - | - | 2.58 |
| BIRC5 | Baculoviral IAP repeat-containing protein 5 | - | - | −2.13 |
| PAWR | PRKC apoptosis WT1 regulator protein | - | - | −1.32 |
| Mcl1b | Myeloid cell leukemia sequence 1 | - | - | −1.13 |
| Set | Protein SET | - | - | −1.03 |
| Regulation of the cytoskeleton by SVCV infection | ||||
| ACTN1 | Alpha-actinin-1 | 0.82 | 0.71 | −1.43 |
| ACTN4 | Alpha-actinin-4 | - | - | −1.45 |
| ACTB | Beta-actin | - | - | −1.35 |
| ARPC5 | Actin related protein 2/3 complex, subunit 5A | - | - | −1.22 |
| TUBA8 | Tubulin, alpha 8 like 2 | - | - | −3.32 |
| TUBB6 | Tubulin, beta 6 class V | - | - | −2.70 |
| TUBA4 | Tubulin alpha-4A chain-like | - | - | −3.08 |
| TUBA1 | Tubulin alpha-1C chain | - | - | −2.66 |
| TUBA2 | Tubulin, alpha 2 | - | - | −2.19 |
| TUBB | Tubulin beta-4 chain-like isoform 1 | - | - | −2.04 |
| TUBA | Tubulin alpha 6 | - | - | −2.00 |
| PFN21 | PFN2l protein | - | - | −1.19 |
| RRAS | Ras-related protein | - | - | −1.23 |
| Gelsolin; | Scinderin like b | - | - | −1.34 |
| RAC1 | Ras-related C3 botulinum toxin substrate 1-like | - | - | −1.37 |
| CFL | Cofilin 2, like | - | - | −1.17 |
| PFN2 | Profilin-2-like isoform 2 | - | - | −1.37 |
| GSN | GSNA | - | −0.78 | −2.05 |
| BRICK1 | Probable protein BRICK1-like | - | - | −2.44 |
| VCL | Vinculin | - | - | −1.34 |
| FLNA; | Vilamin A | - | - | −1.73 |
| COTL1 | Voactosin-like protein | - | - | −2.21 |
| ITGA11 | Integrin alpha-11 | 0.73 | 1.55 | 2.01 |
| Inhibition of the interferon system | ||||
| IFNR1 | IFN-regulatory factor 1 | - | - | 4.77 |
| IRF2 | Interferon regulatory factor 2 | - | - | 2.23 |
| IRFBP2 | Interferon regulatory factor 2-binding protein 2-B | - | 0.66 | 2.59 |
| IRF7 | IFN-regulatory factory 7 | - | - | 3.59 |
*Fold changes refers to the changes of gene expression in response to SVCV infection at the indicated time points, and the minus value means the gene is down-regulated after SVCV infection; while the positive value means the gene is up-regulated in SVCV-infected cells. The dashes (-) indicated that the expression level of certain gene is not changed at the indicated time point post SVCV infection when compared with 0 h post SVCV infection.