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. 2014 Oct 10;46(10):e117. doi: 10.1038/emm.2014.61

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Copyright © 2014 KSBMB.

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/

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Silencing growth hormone receptor (GHR) alters extracellular signal-regulated kinase (ERK) and signal transducers and activators of transcription (STAT) signaling in PANC-1 and HPAC cells. Western blot analysis showing the effect of GHR silenced PANC-1 and HPAC on ERK and STAT signaling. Active and total forms of proteins were analyzed using whole-cell lysates from control and GHR silenced cells. (a, c) The expression levels of phospho-ERK, ERK, insulin receptor-β (IR-β), phospho-insulin receptor substrate-1 (IRS-1), IRS, Ras, insulin-like growth factor-1 receptor (IGF-1R), phospho-STAT3, STAT3, COX-2 and β-actin. The corresponding densitometric analysis is shown to the right of each image (b and d). PS-PANC-1 Scrambled, PG-PANC-1 GHR silenced, HS-HPAC Scrambled, HG-HPAC GHR silenced. Data presented as the mean±s.d. (n=3). *P<0.05.