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. 2014 Oct 29;11:186. doi: 10.1186/s12974-014-0186-3

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© Noailles et al.; licensee BioMed Central Ltd. 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Morphology, number and distribution of microglial cells in the outer plexiform layer (OPL). (A- C) Representative images of whole-mount rat retinas from a SD (A), untreated P23H (B) and tauroursodeoxycholic acid (TUDCA)-treated P23H rat (C) labeled with immunoperoxidase. (E, G, I) Magnifications of (A), (B) and (C), respectively. (D, F, H) Drawings of microglial cells from SD (D), untreated P23H (F) and TUDCA-treated P23H rat (H). (J, K) Microglial density, expressed as number of cells per mm², in each of 12 representative regions in each retina: 6 equidistantly arranged on the superior-inferior axis of the retina (J) and 6 disposed on the temporal-nasal axis (K). The scheme in the margin of each panel represents the position in the retina of each representative region analyzed. (A, B, C) Scale bar: 40 μm; (D, F, H) scale bar: 20 μm; (E, G, I) scale bar: 10 μm.