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. 2014 Nov 6;4:6943. doi: 10.1038/srep06943

Figure 4. Effects of chemical chaperones on PDGF-BB-induced UPR activation and inflammation in CASMC.

Figure 4

(A), (B). Western blotting analysis of ER stress markers in CASMC treated with 0.5 mM 4-PBA (A) and 0.5 mM TUDCA (B) upon chronic stimulation with 20 ng/ml PDGF-BB for 48 h. (C–H). Gene expression analysis of ER stress markers (C, D), inflammatory cytokines (E, F) and PDGF receptors (G, H) in CASMC treated with 0.5 mM 4-PBA and 0.5 mM TUDCA, respectively, upon chronic stimulation with 20 ng/ml PDGF-BB for 48 h. *P < 0.05 vs. Vehicle, †P < 0.05 vs. PDGF-BB.